tecovirimat will boost the stage or result of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Monitor. Tecovirimat is often a weak inhibitor of CYP2C8 and CYP2C19. Observe for adverse consequences if coadministered with delicate substrates of such enzymes.

Reserve concomitant prescribing of such medicines in people for whom other procedure options are inadequate. Limit dosages and durations for the minimal necessary. Check carefully for signs of respiratory despair and sedation.

Drugs which have step therapy connected with Just about every prescription. This restriction typically calls for that specific conditions be satisfied prior to approval to the prescription.

stiripentol will reduce the extent or result of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Intently. Think about lowering the dose of CYP2C19 substrates, if adverse reactions are skilled when administered concomitantly with stiripentol.

miconazole vaginal will enhance the degree or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.

nilotinib will increase the level or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

methylprednisolone will decrease the level or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

Advise patients to avoid driving or functioning hefty equipment right up until affected individual is aware of the results with the drug

Avoid or substitute One more drug for these medications when achievable. Evaluate for lack of therapeutic outcome if medication should be coadministered. Regulate dose Based on prescribing info if wanted.

Because diazepam and its metabolites may be present in human breast milk for extended periods of time after acute use, sufferers needs to be suggested not to breastfeed for an acceptable timeframe after getting therapy

As diazepam rectal gel is just meant for adjunctive use, the prescriber must be sure that the client is receiving an optimal program of normal anti-epileptic drug remedy and it is, Nonetheless, continuing to experience these characteristic episodes

diltiazem will enhance the amount or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.

VALTOCO might make you sleepy or dizzy and will gradual your contemplating and motor capabilities. Do not travel, operate hefty machinery, or do other hazardous functions until finally you understand how VALTOCO affects you.

If click here struggling to avoid coadministration of belzutifan with sensitive CYP3A4 substrates, look at increasing the sensitive CYP3A4 substrate dose in accordance with its prescribing data.